We searched the trial registries for human studies that test collagen, keratin or protein peptides for the gut lining, hair, skin, ageing or women in midlife, registered since January 2025 or with results posted since then. 17 trials are new since our main research page.
What is new
No registered trial names Ovitage®, Tertiary Extracts or sheep (ovine) collagen. We searched ClinicalTrials.gov, the WHO international registry set and the full-text paper indexes.
Gut lining now has collagen trials. Two placebo-controlled trials test collagen peptides on the gut: one measures intestinal permeability (recruiting, primary completion Nov 2026), and one gut discomfort (completed Nov 2025, no results posted yet). See gut lining
Hair trials use keratin and complexes. A 24-week placebo trial of a hydrolysed keratin peptide is complete, and one biotin–collagen–keratin trial has posted results. See hair
Five trials enrol women in midlife or menopause. They include joint pain (Loughborough), genitourinary symptoms (Gemelli, Rome) and a salmon protein hydrolysate for menopause quality of life (Hofseth Biocare). See women
Rousselot is sponsor or collaborator on 5 of the 17 trials (NCT07586930, NCT06937801, NCT07529249, NCT07229014, NCT07195396). GELITA is collaborator on one (VERISOL®).
New Zealand context. Massey University registered a study on ANZCTR in March 2024 on which peptides (including prolyl-hydroxyproline) reach the blood after 15 g of hydrolysed collagen, in healthy women over 50. The record shows ethics as submitted and has not been updated since March 2024. ACTRN12624000354583
The trials
Each card links to its registry record. Status and dates as shown on ClinicalTrials.gov on 8 October 2026. The short description is ours, from the registry entry.
Study Evaluating the Effect of Nutra Harmony "Biotin, Collagen and Keratin Beauty Complex" Dietary Supplement on Hair Thickness and Hair Strength in Adults With Self-Perceived Thinning Hair
Follow-up by the same maker: two biotin doses in the same complex. No placebo arm.
To evaluate the efficacy of two different doses of the study supplement (5,000 mcg vs 10,000 mcg biotin) in adults with self-perceived thinning hair.; To evaluate the efficacy of two different doses of the study supplement (5,000 mcg vs 10,000 mcg biotin) in adults with self-perceived thinning hair.
Dates
Registered 9 Apr 2026 · start 15 Jan 2026 · primary completion 1 May 2026
Dietary Supplements and Middle Aged Women (Collagen & Omega)
About 10 g collagen peptides plus omega-3 a day for 8 weeks against placebo, in women aged 35–65. Primary measure: joint pain. The conditions listed also include sleep, fatigue, body composition, bone markers and gut symptoms.
Sponsor
Loughborough University
Design
Randomised, triple-blind · 34 women 35–65 · United Kingdom
Primary measure
Joint pain under 3 conditions as measured by a 100 mm visual analogue scale (VAS)
Dates
Registered 3 Aug 2026 · start 1 May 2026 · primary completion 1 Aug 2028
Impact of Oral Supplementation With Bioactive Collagen Peptides and Other Functional Ingredients
An oral formula of bioactive collagen peptides and other ingredients (“Collagendep”) for genitourinary syndrome of menopause. Observational cohort, no placebo.
Evaluation of Oral Collagen Peptides on Skin Barrier Function in Women
Two doses (2,000 mg and 5,000 mg) of a collagen peptide product against placebo, in women aged 45–70 with dry, sensitive skin. Rousselot is a collaborator.
Sponsor
Centre de Pharmacologie Clinique Applique a la Dermatologie · with Rousselot BVBA
Design
Randomised, triple-blind · 75 women 45–70 · France
Primary measure
Change in Facial Skin Barrier Integrity Measured by Tewameter After 3 Months of Supplementation
Collagen peptides against placebo for 24 weeks in adults aged 50–70. Primary measures: telomere length and telomerase activity. Collaborator: Collagen Research Institute.
Sponsor
University of Vienna · with Collagen Research Institute
Design
Randomised, quadruple-blind · 125 adults 50–70 · Austria
Primary measure
Telomere length; Telomerase Activity; Change from baseline in DNA-oxidation markers
Dates
Registered 6 Mar 2026 · start 22 Apr 2026 · primary completion Feb 2028
Effects of a Collagen Supplement on Quality of Life, Appetite and Glycaemic Control
5 g bovine collagen peptides twice a day for 8 days against placebo. Measures: quality of life, appetite, sleep, mood and blood glucose. Rousselot is a collaborator.
Sponsor
King's College London · with Rousselot BVBA
Design
Randomised, triple-blind · 100 adults 18–65 · United Kingdom
Primary measure
Quality of life scores
Dates
Registered 14 Nov 2025 · start Dec 2025 · primary completion Jan 2027
Clinical Effects of Two Oral Bioactive Collagen Peptides On Skin Properties and Aging Hallmarks
A collagen peptide sachet (2,500 mg a day for 8 weeks) against a competitor collagen product, in women aged 35–65.
Sponsor
Bionos Biotech S.L.
Design
Randomised, quadruple-blind · 67 women 35–65 · Spain
Primary measure
Quantification of the change in facial wrinkle parameters (area, length, depth, and volume) in the crow's-feet region from baseline to post-treatment visits using 3D imaging.; Quantification of the change in facial skin firmness, elasticity, and fatigue from baseline to post-treatment visits using Cutometer®.; Quantification of the change in facial skin hydration and transepidermal water loss (TEWL) from baseline to post-treatment visits using Corneometer® and Tewameter®.
Dates
Registered 24 Dec 2025 · start 26 Feb 2025 · primary completion 23 Apr 2025
To Collect Enriched Human Serum Following Hydrolyzed Collagen Intake
Five collagen hydrolysates (single 10 g dose each) in women aged 35–45, to collect serum rich in collagen-derived di- and tripeptides. Sponsor: Rousselot.
Sponsor
Rousselot BVBA · with BioTeSys GmbH
Design
Randomised, triple-blind · 3 women 35–45 · Germany
Primary measure
collagen-derived di- and tripeptides
Dates
Registered 26 Sep 2025 · start 22 Oct 2025 · primary completion 22 Dec 2025
Recent papers to read next
Published 2025–2026, found in the full-text index. Listed by title only: we have not yet read or appraised these papers.
Search: 20 queries (collagen, keratin and protein peptides × menopause, hair, gut barrier, skin, bone, muscle, ageing, GLP-1) on the Paperclip trial index of ClinicalTrials.gov and the WHO international registry set. 316 ClinicalTrials.gov records came back.
Each record was then read from the ClinicalTrials.gov API on 8 October 2026. We kept collagen, keratin and peptide trials taken by mouth that were registered from 1 January 2025 or posted results since then. We left out devices, dental and wound products, injections, drug trials, and one survey of self-chosen supplements after bariatric surgery.
Seven trials already on the main research page are not repeated here.
Limits: this is a first pass. We read registry entries, not protocols or papers. The international registries (including ANZCTR, ChiCTR, JRCT and the EU register) were searched but not reviewed record by record. Results posted on a registry are not peer-reviewed.
Prepared by Articulate AI for Tertiary Extracts · 8 October 2026 · research notes only, not health advice.